Pregnenolone

The Superhormone for Your Brain

Potent memory enhancer, relieves arthritis, Anti-depressant; converts to progesterone and DHEA (dehydroepiandrosterone) in the body.

What is Pregnenolone?

Pregnenolone is a natural hormone, produced primarily by the adrenal glands, but also in the brain, liver, skin, testicles and ovaries. In the body Pregnenolone is used as Pregnenolone itself, or it is converted to DHEA (dehydroepian- drosterone), which in turn is converted into Androgens (e.g. Testosterone), Estrogens and other steroids, and through another pathway, it is converted into Progesterone. Totally over 150 different steroid hormones are made from Pregnenolone in the body - it generates a whole symphony of hormones - in short "The Symphony of Life". It is interesting to note, that there is a clear difference in the metabolism of Pregnenolone in human males and females - in males the metabolic pathway seems to favor conversion into Testosterone and in females the conversion into Estrogens.

About Pregnenolone

If DHEA is referred to as "The Mother Hormone", Pregnenolone will qualify to be called "The Grandmother Hormone". Pregnenolone was first prepared in a laboratory in 1934. It has been clearly established that with age, the natural secretion of related hormones, including Pregnenolone, enzymes and other important bodily substances, drastically goes down - substances that are vital in order to have a functioning body and mind - as well as all other bodily functions do. One may ask: "What is the chicken and what is the egg, in this case?"

What Does Pregnenolone Do?

Clinical research has shown Pregnenolone to be important for nerve and brain health, having also been found to be a potent memory and learning skill enhancer - maybe the most important so far discovered. It is also known to relieve arthritis. Pregnenolone has been used in treating depression, relieving stress, improving mood and sense of well-being. Additionally, it stimulates clear thinking, improves concentration, enhances alertness and promotes an overall better mental function/alertness, all supporting improved creativity, making you think clearer and faster, keeping the brain functions at peak capacity, increasing the desire to learn and try new things. Pregnenolone also possibly influences the (psychic) energy levels. In studies Pregnenolone has been found to have a positive effect on Alzheimer’s, Multiple Sclerosis, Parkinson’s, seizures, Chronic Fatigue Syndrome (CFS), Diabetes as well as on Autoimmune disorders, such as Lupus and Scleroderma, Heart Disease, Muscle Building, the Immune System, Cholesterol levels, vision and hearing, PMS, Benign Prostate Hyperplasia, skin quality and weight loss.

Pregnenolone has also been tested with promising results in spinal cord and nerve injuries, due to accidents or disease. It is only fair to assume, that shortly Pregnenolone will prove to be instrumental in the Aging Process and Longevity and play a very important role in over-all Quality of Life. In the body Pregnenolone synthesizes into Progesterone, and via DHEA (dehydroepiandrosterone) into Testosterone and Estrogen. Further human studies are required in order to know the exact and the extent of these effects on human beings.

What are the Benefits of Supplemental Pregnenolone?

• Brain
  Pregnenolone plays a significant role in brain health. Because of Pregnenolone’s proven biochemical effects on the brain and the brain chemistry, it is only a fair hypothesis to make, that it would be one solution to treating diseases like: Anxiety, Obsessive-Compulsive Disorder (OBD), Dementia, Depression, Manic-depression, Alzheimer’s, Parkinson’s and aging in general, resulting in better memory, mood, well-being; peacefulness, mild euphoria, clear thinking, mental alertness, (psychic) energy, creativity, speech and vision.
• Stress
  Stress - no matter the source - causes elevated cortisol levels, with increased blood sugar levels, inhibition of the immune system, calcium loss (leading to osteoporosis) as a result. Pregnenolone, especially in combination with Melatonin, has proven to be very effective in relieving stress and stress symptoms.
• Energy
  Pregnenolone has anti-fatigue effects, both physiologically ("more pep"), as well as psychically - more mental energy.
• Vision & Hearing
  There are proofs that Pregnenolone provides enhanced visual and auditory perception.
• Estrogen/Hormone-Replacement Therapy (ERT-HRT)
  Can Pregnenolone be a replacement for traditional ERT/HRT?! Research indicates that this may be the case, especially together with DHEA (dehydroepiandrosterone), and complemented with human female hormones. The trick is to find the individual right combination of the supplemental hormones (Pregnenolone, DHEA, Melatonin, etc.) and the replacement hormones (e.g. Estrone, Estriol, Estradiol) and the ratio of the two types. More research is no doubt needed, but we have after all come a long way and the general information given in the literature, presented in this brochure, must be considered as "safe and efficacious".
• Arthritis & Autoimmune disorders
  Treatment with Pregnenolone has shown marked clinical improvement in patients with Ankylosing Spondylitis, Lupus, Osteo- and Rheumatoid Arthritis and Scleroderma.
• Neurological Help
  Pregnenolone has also been used in treating Alzheimer’s Disease, Multiple Sclerosis (MS), nerve injuries, Parkinson’s Disease and seizures.
• Depression
  Pregnenolone has been successfully used in counteracting all types of depression.
• Other Indications
  Pregnenolone has been used in the treatment of Chronic Fatigue Syndrome/"CFS", Addison Disease, high cholesterol levels, Immune System-deficiencies and skin conditions.
• Anti-Aging/General Health and Well Being/Quality of Life/Longevity
  Regardless of whether Pregnenolone lengthens the lifespan, it is evident that it does have some important therapeutic application, and used wisely, it may improve the Quality of Life and postpone signs of aging or the aging process itself, while improving general health and sense of well-being. A great deal of research is underway and it will give us answers about the effects of long-term use.
  
  

Pregnenolone is Safe to Use

No serious side effects or risks have been reported in association with taking supplemental Pregnenolone in recommended doses (see below). Neither has any toxicity been seen even in dosages several times greater than the generally recommended dose, given over a long period of time.

Pregnenolone seems to be compatible with - and causes no negative (drug-) reactions whatsoever - all and any prescription drug, other dietary supplement, natural products and foods, when taken in recommended dosage.

Pregnenolone and DHEA in Combination

Although Pregnenolone is a precursor to Progesterone and DHEA, which in turn is a precursor to several other hormones, e.g. all of our sex hormones (Testosterone, Estrogen, only to name a few), it is important to understand, that the conversion rate of Pregnenolone to these hormones is slowed down even more with age, than the actual production in the body of the hormones themselves. When we age, the enzymes secreted by the body governing the conversion of Pregnenolone to DHEA, is secreted at an even slower rate, than the applicable hormone secretions themselves. Therefore a "Hormone Cocktail"/a mix of these hormones is preferable, as we age. Both Pregnenolone (mainly for "its own" function as Pregnenolone - memory/mental alertness, mood/well-being, arthritis and for nerve/spine cell stimulation/regeneration) and DHEA (for its many well known important and beneficial physiological functions) can - and in most cases should - be taken together in recommended dosages.

What is recommended Intake?

Unless otherwise prescribed by a physician, only individuals over the age of 40 should be taking this product, as the levels of Pregnenolone prior to that age are usually sufficient. Take 10-50 mg daily, or according to doctor’s prescription. Take capsule in the morning on an empty stomach. For long-term continuous usage a physician should be consulted to establish the correct daily dosage. For healthy adults, 10 mg is recommended for people of 40 years of age, 25 mg for people over 50 years of age and 50 mg for people over 60 years of age, as general guidelines. Blood levels of Pregnenolone should be measured regularly - especially in younger subjects - to determine if supplementation is appropriate and a physician should monitor the dosages.

Download Factsheet PDF